Republican Sen. John McCain said Thursday that President Barack Obama is "directly responsible" for the mass shooting in Orlando, Florida, because of the rise of the Islamic State group on the president's watch. But he later issued a statement saying that he "misspoke."

The Republican primary is three months away, but U.S. Sen. John McCain already has his eyes on the general election and is taking an early shot at his likely Democratic opponent.

U.S. Sen. John McCain acknowledged that Donald Trump’s presence at the top of the Republican ticket could make for a more perilous path to re-election, but said he was still confident that he would win a sixth term in November.

U.S. Sen. John McCain on Friday called for a criminal investigation into actions by the Environmental Protection Agency that led to a mine spill polluting rivers in three Western states last summer.

Sen. John McCain, R-Arizona, will not attend the Republican National Convention in Cleveland this July but will be “working and campaigning throughout Arizona,” a campaign official confirmed Tuesday.

The Obama administration's fight against the Islamic State is at risk of becoming a "grinding failure for our nation," an influential Republican senator said Tuesday in a broadside that illustrated the mounting frustrations in Congress with the U.S. strategy to defeat the extremist group.

Supporters of a copper mine proposed for Oak Flat have been given until Friday to make the case that the area, deemed sacred by the San Carlos Apache, should not be designated a historic site.

Arizona Senator John McCain is joining some fellow Republican senators in saying that President Barack Obama's successor should fill the U.S. Supreme Court vacancy created by the death of Justice Antonin Scalia.

The Air Force has delayed plans to retire the A-10 Warthog, a jet fighter that is a mainstay of the Davis-Monthan Air Force Base in Tucson, according to a published report.

The Republican Party of Maricopa County said Sunday that precinct committeemen approved a resolution to support another candidate